Relation between TNF-α genetic polymorphism and primary lung cancer

Objective: Single nucleotide polymorphism (SNP) in the promoter region of tumor necrosis factor-α (TNF-α) is found to be related to some inflammations and tumors. In this study, we aimed to confirm the correlation between TNF-α-308G/A polymorphism and susceptibility to primary lung cancer among Chinese population. Method: Genotyping was performed for TNF-α-308G/A polymorphism (rs1800629 locus) using high-throughput TaqManMGB probe. The genotype distributions in 500 healthy subjects and 500 patients with primary lung cancer were compared. Results: The frequency of GG genotype of TNF-α-308G/A polymorphism was 70.8% in case group and 88.2% in control group. The frequency of AG genotype was 21.0% in case group and 8.6% in control group. The frequency of AA genotype was 8.2% in case group and 3.2% in control group. The carriers of GA (OR=3.042, 95%: 2.077-4.454, P<0.001) and AA genotype (OR=3.192, 95% CI: 1.761-5.784, P<0.001) have higher risk of lung cancer. Logistic regression analysis remains the significance (T allele vs. G allele, OR=2.665, 95% CI: 1.342~4.142, P=0.008). Conclusion: TNF-α-308G/A polymorphism was significantly associated with susceptibility to primary lung cancer in a Chinese population.